The Biological Bulletin, October 1st, 2004
The molecular motors myosin-V and kinesin form a complex to transport vesicles within the neuron. Vesicles move long distances along microtubule tracks using kinesin motors and then switch to actin filaments for short distance movement using myosin-V motors. Affinity isolation of native kinesin with a glutathione S-transferase-tagged myosin-V globular tail fusion protein provided evidence that the two proteins can interact with one another to form a heteromotor complex. This complex provides a mechanism by which one motor can regulate the activity of the other, enabling vesicles to switch ea...
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