Indian Journal of Pharmacology, September 1st, 2005
www.innovation.org [Figure 1 ] The process of drug discovery has seen many transformations. In the post World War II era, medicinal synthetic organic chemistry and pharmacology were the prime drivers of pharmaceutical innovation which in turn fuelled a highly successful and profitable industry. Medicinal chemists made structural analogues of known and newly discovered active molecules with the objective of mimicking their functions which were then optimised for therapeutic use after a long drawn out process. This "me-too" approach became unsustainable because of newer discoveries in the disea...
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