Biophysical Journal, April 1st, 2006
ABSTRACT
Lattice modeling is applied to investigate how the configurations of local chain juxtapositions may provide information about whether two ring polymers (loops) are topologically linked globally. Given a particular juxtaposition, the conditional probability that the loops are linked is determined by exact enumeration and extensive Monte Carlo sampling of conformations satisfying excluded volume constraints. A discrimination factor f^sub L^, defined as the ratio of linked to unlinked probabilities, varies widely depending on which juxtaposition is presumed. |log f^sub L^|s that are lar...
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