Clinical Chemistry, June 1st, 2004
Seizures occur in ~5% of people, and recur in >20% of that 5% (1, 2). The etiologies of most seizures are unknown, and head trauma is implicated in only 5-10% of cases (3). Blood or blood components, specifically iron, may be etiologically important; intracranial injection of hemoglobin (4), lysed erythrocytes (5), iron-containing proteins (5), or iron salts (6) produced chronic focal spike activity in rodents and cats. Because microhemorrhagic events occur in the central nervous system of all people, inadequate clearance of iron-rich (7) hemoglobin might underlie development of some seizur...
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