The Scientist, October 14th, 2002
Panomics' array-based kits map transcription factor networks
A single human cell contains around 2,000 transcription factors, estimates Jason Li, president and CEO of Panomics in Redwood City, Calif. Their shifting alliances comprise a powerful layer of gene expression regulation, and can change depending on the specific function of the cell, micro- and macro-environmental factors, or particular experimental treatments. But standard detection methods, such as gel shifts and immunoprecipitations, permit isolation of only single molecular interactions, "one by one, one protein to the other," he...
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