Regional Anesthesia and Pain Medicine, January 1st, 2004
To the Editor:
The significance of barbiturate hyperalgesia in the postoperative setting, first suggested by Glutton-Brock more than 40 years ago,1 has not received any attention since our publication in 1994 of results that did not demonstrate an effect in the first 48 hours after surgery, and we concluded then that it was of little clinical relevance.2 After subhypnotic doses of thiopentone, the pain threshold may be increased in the very short term3 and the appropriate management of acute pain after surgery using a balanced approach to reduce its intensity serves to mask any early effect t...
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