Hurler's Syndrome, often called gargoylism, is a rare hereditary and congenital metabolical disorder that is inevitably lethal when untreated. The term gargoylism has been applied to this syndrome because the gross disfiguration resembles the gargoyles of Gothic architecture. Hurler's Syndrome is a lysosomal storage disease that leads to the accumulation of dermatan sulfate, which cause major abnormalities primarily affecting the central nervous system. The condition was given the name Hurler's Syndrome when, in 1919 while training in pediatrics, Hurler described a syndrome of corneal clouding, dwarfing skeletal dysplasia, spinal malalignment and mental retardation. Despite the fact that the condition was first observed by John Thompson nineteen years earlier, the disease is most commonly called Hurler's Syndrome. Other names for Hurler's Syndrome include Alpha-L-iduronidase deficiency syndrome, dysostosis multiplex, dysostotic idiocy, gargoylism, lipochondrodystrophy, Hurler-Hunter syndrome, Johnie McL disease, and many more.

Onset of Hurler's Syndrome usually takes place in infants six...