Summary:
The purpose of the article is telling us that the two dimensional crystal structure of a membrane protein is the first step to have better understand how an E. Coli infection begins and new protein structure is a first step toward preventing E. Coli disease.
Current Biological Event
1. Bibliographical Information: Author: HuiLin LiDate: 2004-11-22
Title: New Protein Structure Is A First Step Toward Preventing E.Coli Diseases.
Source: Brookhaven National Laboratory
URL: http://www.sciencedaily/com/releases/2004/11/041116232602.htm
- Summary of Content: The purpose of the article is telling us that the two dimensional crystal structure of a membrane protein is the first step to have better understand how an E. Coli infection begins and new protein structure is a first step toward preventing E. Coli disease. E. Coli can produce one of the most prevalent diseases in the U.S., urinary tract infections. Understanding how an E. Coli infection begins is the fundamental key to block the disease. E. Coli binds to human kidney cells and use an "adhesive protein" secreted by the cells through a membrane protein "channel" which shows how secretion occurs and read to the scientist to prevent E. Coli from attaching to the human cell. The protein cell is called "Pap C' which help certain substances to leave a cell and prepare the substance for secretion. Scientists discovered that the protein channel has two main structural elements with pores. They assume that the twin pore configuration coordinate the assembly and secretion of the adhesive. Because the scientists knew that the greater understanding of how the adhesive protein is assemble and secreted can aid in the study and treatment of the urinary tract infections and other related diseases, they grew a two-dimensional crystal of Pap C and used cryo-electron microscopy to image individual proteins in the crystal. This method gave scientists a top-down image of the protein channel from a "un tilted" sheet of crystals.
- Analysis and Evaluation: I think this research is very awesome because it gives us the hope that less people will suffer from E. Coli infection, urinary tract infection. I recalled from chapter eight-section one "cell growth." Cells can grow at astonishing rates, the bacterium, Escherichia Coli or E. Coli, is a single celled (prokaryotic) organism that can easily double its volume in about 30 minutes. It can then divide to from two new cells. That means we have more chance to have urinary tract infections. As the article said, urinary tract infections is on e of the most prevalent diseases in the U.S. if we have better understanding about the two dimension crystal structure of a membrane protein involved in urinary tract infection, then we have the better chance to easily approach the cause of the infection and block the infection at first place. Therefore, more people can benefit from the blocking infection of E. Coli, and E. Coli not only cause the urinary tract infection, which is one of the most prevalent diseases in U.S.A., but also trigger other diseases, which cause the death of lives.
This is the complete article, containing 452 words
(approx. 2 pages at 300 words per page).
