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Lennie doesn`t know his own strength. When he was frustrated or nervous he had even less control of what he is doing. For example, Lennie broke Curly's hand and he accidentally killed Curly's wife that was done partially by fear. People around Lennie, except for George, didn't understand him and they weren't use to a man making many mistakes.
Lennie's strength had his benefits and had its downs. Lennie not knowing his own strength was a great disadvantage to him and to part of his surroundings. If Lennie had more people around him who understood him and could help him, he could have more control of his strength or had less troubles. Lennie strength is his own enemy.