On the death of Don Diego de Azevedo, Don Diego de Zuniga by Velasco, Conde de Nieva, was appointed to supersede the Marquis of Cannete as viceroy of Peru, and departing from Spain to assume his new office in January 1560, he arrived at Payta in Peru in the month of April following. He immediately dispatched a letter to the marquis informing him of his arrival in the kingdom as viceroy, and requiring the marquis to desist from any farther exercise of authority. On the arrival of the messenger at Lima, the marquis ordered him to be honourably entertained, and to receive a handsome gratification, to the value of 7000 dollars; but he forfeited all these advantages, by refusing to address the ex-viceroy by the title of excellency. This slight, which had been directed by the new viceroy, so pressed on the spirits of the marquis, already much reduced by the infirmities of age and the ravages of a mortal distemper, that he fell into a deep melancholy, and ended his days before the arrival of his successor at Lima.
The Conde de Nieva did not long enjoy the happiness he expected in his government, and he came by his death not many months afterwards by means of a strange accident, of which he was himself the cause; but as it was of a scandalous nature I do not chuse to relate the particulars. On receiving notice of his death, King Philip II. was pleased to appoint the lawyer Lope Garcia de Castro, who was then president of the royal council of the Indies, to succeed to the government of Peru, with the title only of president of the court of royal audience and governor-general of the kingdom. He governed the kingdom with much wisdom and moderation, and lived to return into Spain, where he was replaced in his former situation of president of the council of the Indies.
Don Francisco de Toledo, second son of the Conde de Oropeta, succeeded Lope Garcia de Castro in the government of Peru, with the tide of viceroy. He had scarcely been two years established in the government, when he resolved to entice from the mountains of Villcapampa where he resided, the Inca Tupac Amaru, the legitimate heir of the Peruvian empire, being the son of Manco Inca, and next brother to the late Don Diego Sayri Tupac, who left no son. The viceroy was induced to attempt this measure, on purpose to put a stop to the frequent robberies which were committed by the Indians dependent on the Inca, in the roads between Cuzco and Guamanga, and in hope of procuring information respecting the treasures which had belonged to former Incas and the great chain of gold belonging to Huayna Capac, formerly mentioned, all of which it was alleged was concealed by the Indians. Being unable to prevail upon the Inca to put himself in the power of the Spaniards, a force of two hundred and fifty men was detached into the Villcapampa, under the command of Martin Garcia Loyola, to whom the Inca surrendered himself, with his wife, two sons, and a daughter, who were all carried prisoners to Cuzco.