Sexually transmitted disease caused by the spirochete Treponema pallidum. Without treatment, it may progress through three stages: primary, characterized by a chancre and low fever; secondary (weeks to months later; only half of those infected display symptoms), with a skin and mucous-membrane rash, lymph node swelling, and bone, joint, eye, and nervous system involvement; and tertiary. The tertiary stage follows a latency period that can last years, and only one-fourth of those infected display tertiary symptoms.
These can be benign or incapacitating and even fatal; almost any part of the body may be attacked. Syphilis can spread to a fetus from an infected mother. Other species of Treponema cause similar but milder, nonsexually transmitted forms of syphilis (&see; yaws). Several blood tests can detect syphilis, even during latency. Antibiotic treatment is effective.
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