Krebs, Sir Hans Adolf

(born Aug. 25, 1900, Hildesheim, Ger.—died Nov. 22, 1981, Oxford, Eng.) German-born British biochemist who received (with Fritz Lipmann) the 1953 Nobel Prize for Physiology or Medicine for the discovery in living organisms of the series of chemical reactions known as the tricarboxylic acid cycle (also called the citric acid cycle, or Krebs cycle). These reactions involve the conversion—in the presence of oxygen—of substances that are formed by the breakdown of sugars, fats, and protein components to carbon dioxide, water, and energy-rich compounds.

At the University of Freiburg (1932), Krebs discovered (with the German biochemist Kurt Henseleit) a series of chemical reactions (now known as the urea cycle) by which ammonia is converted to urea in mammalian tissue; the urea, far less toxic than ammonia, is subsequently excreted in the urine of most mammals. This cycle also serves as a major source of the amino acid arginine.

The son of a Jewish physician, Krebs was forced in 1933 to leave Nazi Germany for England, where he continued his research at the University of Cambridge (1933–35). At Sheffield University, Yorkshire (1935–54), Krebs measured the amounts of certain four-carbon and six-carbon acids generated in pigeon liver and breast muscle when sugars are oxidized completely to yield carbon dioxide, water, and energy.

In 1937 Krebs demonstrated the existence of a cycle of chemical reactions that combines the end-product of sugar breakdown, later shown to be an “activated” form of the two-carbon acetic acid, with the four-carbon oxaloacetic acid to form citric acid. The cycle regenerates oxaloacetic acid through a series of intermediate compounds while liberating carbon dioxide and electrons that are immediately utilized to form high-energy phosphate bonds in the form of adenosine triphosphate (ATP; the chemical-energy reservoir of the cell). The discovery of the tricarboxylic acid cycle, which is central to nearly all metabolic reactions and the source of two-thirds of the food-derived energy in higher organisms, was of vital importance to a basic understanding of cell metabolism and molecular biology.

Krebs served on the faculty of the University of Oxford from 1954 to 1967. He wrote (with the British biochemist Hans Kornberg) Energy Transformations in Living Matter (1957) and also coauthored (with Anne Martin) Reminiscences and Reflections (1981). He was knighted in 1958, and the Royal Society awarded him its Copley Medal in 1961.

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