(1494–1559) Series of violent wars for control of Italy. Fought largely by France and Spain but involving much of Europe, they resulted in the Spanish Habsburgs dominating Italy and shifted power from Italy to northwestern Europe and its Atlantic world. The wars began with the invasion of Italy by the French king Charles VIII in 1494. He took Naples, but an alliance between Maximilian I, Spain, and the pope drove him out of Italy. In 1499 Louis XII invaded Italy and took Milan, Genoa, and Naples, but he was driven out of Naples in 1503 by Spain under Ferdinand V.
Pope Julius II organized the League of Cambrai (1508) to attack Venice, then organized the Holy League (1511) to drive Louis out of Milan. In 1515 Francis I was victorious at the battle of Marignano, and in 1516 a peace was concluded by which France held onto Milan and Spain kept Naples. Fighting began in 1521 between Emperor Charles V and Francis I. Francis was captured and forced to sign the Treaty of Madrid (1526), by which he renounced all claims in Italy, but, once freed, he repudiated the treaty and formed a new alliance with Henry VIII of England, Pope Clement VII, Venice, and Florence. Charles sacked Rome in 1527 and forced the pope to come to terms, and Francis gave up all claims to Italy in the Treaty of Cambrai (1529). By the Treaty of Cateau-Cambrésis (1559), the wars finally ended.
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