One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes.
Its structure, with two strands wound around each other in a double helix to resemble a twisted ladder, was first described (1953) by Francis Crick and James D. Watson. Each strand is a long chain (polymer) of repeating nucleotides: adenine (A), guanine (G), cytosine (C), and thymine (T). The two strands contain complementary information: A forms hydrogen bonds (&see; hydrogen bonding) only with T, C only with G. When DNA is copied in the cell, the strands separate and each serves as a template for assembling a new complementary strand; this is the key to stable heredity. DNA in cells is organized into dense protein-DNA complexes (&see; nucleoprotein) called chromosomes. In eukaryotes these are in the nucleus, and DNA also occurs in mitochondria and chloroplasts (if any). Prokaryotes have a single circular chromosome in the cytoplasm. Some prokaryotes and a few eukaryotes have DNA outside the chromosomes in plasmids. &Seealso; Rosalind Franklin; genetic engineering; mutation; Maurice Wilkins.
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