<math>xy</math> coordinates, used to locate a point in two dimensions according to the cartesian coordinate system.

XY sex-determination system in biology.

Kyle XY a television show broadcast by the American Broadcasting Company.

X&Y, an album by Coldplay.

Xy (used to be known as Xytras) is a member of the band Samael.

XY Magazine is a magazine published in the United States that also operates a personals website. Both are intended for young gay, bi, and lesbian youth.

XY problem is a term from computer programming. It is when a person has a problem X, and thinks Y is the proper solution, and asks how to do Y.

XY model in physics.