The Wesley family, founders of the Methodist Church, including:

Eugene Wesley Roddenberry, American scriptwriter and producer

Mary Wesley, British author

John Wesley Hardin, well-known outlaw and gunfighter in late 19th-century Texas

Wesley Snipes, American actor

Wesley Brown, English Professional Footballer, plays in defence for Manchester United.

Wesley So, chessplayer

Wesley College (disambiguation)

John Wesley, the Founder of the Methodist denomination of Protestant Christianity

Charles Wesley, prolific hymn writer, and brother of John Wesley

Samuel Wesley, organist, composer, and son of Charles Wesley

Samuel Sebastian Wesley, organist, composer, and son of Samuel Wesley

Glen Wesley, NHL hockey player

Wesley Borland, a musician (formerly of Limp Bizkit, now working with Black Light Burns).

Wesley, a village in Dominica

Wesley, a town in northern Iowa

Wesley Medical Center, a hospital in Wichita, Kansas

Wesley Wyndam-Pryce, character from Angel (TV series), originally introduced in Buffy the Vampire Slayer

Wesley Crusher, character from Star Trek: The Next Generation

Westley, character from The Princess Bride