Relative direction, where up is the opposite of down

University of Pennsylvania, in the United States

μp, an abbreviation for "microprocessor" (where the "u" is actually "μ", the lowercase Greek letter mu, meaning "micro-")

Experiencing the effects of psychoactive drugs

University of Pretoria, in South Africa

University of the Philippines, in the Philippines

Up, a type of quark

Uttar Pradesh, an Indian state

Union Pacific Railroad, a US railroad network

Upper Peninsula of Michigan, in the United States

Patriotic Union, a political party of Colombia

United Press International, a press agency

University of Portland, in the United States

University of Patras, in Greece

Unified Process

University of Porto, in Portugal

The album Up by American rock band R.E.M.

The album Up by British musician Peter Gabriel

The album Up! by Canadian singer Shania Twain

A University Press at any major university

Universidad Panamericana, in Mexico

The Volkswagen up! concept car seen at Frankfurt Motor Show

Bahamasair, IATA airline designator

Unia Pracy (Labor Union), a political party of Poland

At bat, in baseball, when a player is facing the pitcher

Up (2009 film) by Pixar Animation Studios

Unambiguous Non-deterministic Polynomial-time

United Planet, a US organization dedicated to enhancing cross-cultural & geographical understanding

Unity Party, the name of political parties in several countries

Univerzita Palackého, in the Czech Republic

The album Up by Canadian folk-rock group Great Big Sea

United Party, the name of political parties in several countries

Universidade Pedagógica, in Mozambique