Natural selection

Unnatural Selection (video game) is the name of a videogame released by Maxis.

Unnatural Selection (Buffy novel), an original novel based on the television series Buffy the Vampire Slayer

"Unnatural Selection" (Stargate SG-1), an episode of the science fiction television series Stargate SG-1

Artificial selection

"Unnatural Selection" (The Outer Limits), an episode of The Outer Limits television show

Saurians: Unnatural Selection (comics), American comic book published by CrossGen Entertainment from February 2002 to March, 2002

"Unnatural Selection" (TNG episode), an episode in the second season of Star Trek: The Next Generation