A tome is a large book, often one volume of a multi-volume scholarly work. It may also refer to:

Tome-Adelino, a city in New Mexico

"Philippe Tome", a pseudonym used by writer Philippe Vandevelde

ToME, a roguelike computer game

Tome, Miyagi, a city in Japan (formerly Tome District)

TV Tome, was a United States website for television information, successor: TV.com

Tome School, a prep school located in North East, Maryland.