The Scarlet Letter, written by Nathaniel Hawthorne, published in 1850

The Suite Life of Zack & Cody, an American comedy sitcom

Teen Second Life, a version of Second Life reserved for teenagers

The Simple Life, Paris Hilton and Nicole Richie

Transport Secure Layer, provide secure communications on the Internet

Star Wars: Knights of the Old Republic II: The Sith Lords, a video game

Trina Solar Limited, a Chinese solar company traded on the New York Stock Exchange under the ticker "TSL".

This Sporting Life, an Australian radio comedy show

Turkcell Super League, the top-flight league in Turkish nationwide football

This Spartan Life, a machinima talk show

The Starting Line, a pop punk band from the Philadelphia, Pennsylvania area

Test-and-set lock, an atomic operation used for computer program synchronization

Trustix Secure Linux

Turkish Sign Language, used by the deaf community in Turkey

Trisyllabic laxing

TSL color space based on Tint, Saturation, and Luminance

The Silver Lining (disambiguation)

Transmitter/studio link, sends telemetry data from the remotely-located transmitter back to the studio for monitoring purposes

The Software Link, a former software company

TSL Limited, a Zimbabwean company

Time spent listening, one of the measurements surveyed by Arbitron in determining ratings for radio stations in the U.S.