The History Channel

Thermohaline circulation, an ocean current

Texas Historical Commission

Tan Holdings Corporation

Tetrahydrocannabinol, the main active chemical compound in Cannabis

Tenet Healthcare, an American healthcare provider; THC is its stock ticker symbol on the New York Stock Exchange

The Harvard Crimson, the student newspaper of Harvard University

T.H.C., a band that plays trip hop and electronica music.

THC may also refer to a modified dashboard for the Xbox game console, which later was replaced with UIX.