A substitute teacher, and any of a series of movies about fictional crime-fighting substitute teachers.

Substitute (song), a 1966 song by The Who appearing on the album Meaty Beaty Big and Bouncy

Substitute chord, an alternative chord used in jazz harmony

Substitute good, a classification of goods or services in economic theory.

Interchange (Australian rules football), in Australian Rules Football

Substitution (law), a legal right to change a judge that may be biased.

Substitute character, the hexadecimal code number 0x1A in the ASCII character set.

Substitute flag, part of the international maritime signal flag set

Football (soccer) - see Substitute (football)

Cricket - see Substitute (cricket)