The Andromeda Strain is a science fiction book and movie adaptation

Strain (materials science), the deformation of materials caused by stress

Strain (manga), manga written by Yoshiyuki Okamura, and illustrated by Ryoichi Ikegami

Lunar Strain, the 1994 music album by In Flames

The Acacia Strain, an American band

Strain (injury), an injury to a muscle in which the muscle fibers tear as a result of over stretching

Isaac Strain, an American explorer

Strainer, a type of sieve used to separate solids from liquids, e.g. in cooking.

Christina Strain, a comic book artist (colorist)

Julie Strain, an American actress and model

New Business Strain, a financial concept

Shear strain, a strain that acts parallel to the face of a material that it is acting on

Ames strain, a strain of anthrax

Strain (biology), a variant of a plant, virus or bacterium; or an inbred animal used for experimental purposes

Strain theory, of which there are several

Ring strain, another chemical concept

Strain (chemistry), a chemical stress of a molecule

Strain (music), a series of musical phrases that create a distinct melody of a piece

Strained tendon, a German band

Strain 121, a microbe that can thrive at temperatures of 121°C