Stapleton (fictional character), a character in the stories written by Arthur Conan Doyle

Gerald Stapleton

Stapleton International Airport, a former airport in Denver.

Stapleton, Staten Island, a neighborhood in New York City

Nicola Stapleton, English actress

Rita Stapleton, a heroine on the CBS soap opera The Guiding Light during the 1970s and early '80s

Frank Stapleton, Irish soccer player

Dave Stapleton, a former Major League Baseball player for the Boston Red Sox

Maureen Stapleton, American actress

Stapleton, Bristol

Pat Stapleton, NHL ice hockey player

Jim Stapleton

Stapleton, Leicestershire

Miles Stapleton

Stapleton, Alabama

Jean Stapleton, American actress best known for her role in the television series All in the Family

Stapleton, Nebraska

Stapleton, Georgia

Mike Stapleton

Steven Stapleton, leader of the British experimental music group Nurse with Wound

Philip Stapleton

Theobald Stapleton, 17th-century Irish priest

Craig Roberts Stapleton, the U.S. ambassador to France

Bob Stapleton

Paul Stapleton

Benjamin F. Stapleton, a former mayor of Denver, Colorado

Darren Stapleton

Peter Stapleton

Stapleton (band), a rock band from Glasgow.

Stapleton, Herefordshire

Ruth Carter Stapleton

Eddie Stapleton, Australian Wallabies rugby winger who also played for the New Zealand All Blacks

Fergal Stapleton

Tim Stapleton

Clay Stapleton

John Stapleton

Sally Stapleton

Rory Stapleton

Brett Stapleton

Walter King Stapleton

Jacinta Stapleton

Stapleton, Richmondshire, North Yorkshire

Darnell Stapleton

Sheryl Williams Stapleton