Action potential, a concept in neuroscience

Spike (TV channel)

Nail (fastener), especially one over four inches long

Spike (Cowboy Bebop), a character from Cowboy Bebop

A nickname for the Spire of Dublin

Spike, a 1989 album by Elvis Costello

Spike (missile)

The act of driving a spike into a tree, making it dangerous to cut with a chainsaw.

Spike (MGM), a recurring character on Tom and Jerry

Spike (given name)

Track spikes, shoes worn during track and field events

Voltage spike, also called an electrical surge

Spike, a 2001 album by Puffy AmiYumi

Poolsbrook, a village in Derbyshire formerly known as Spike

Spike (stagecraft), a theatrical term

Spike Shooter, a sports energy drink

A type of raceme with sessile flowers

Spike bayonet, an attachment for a firearm

Rail spike, used to construct railroad tracks

The Spike, a 1980 novel by Arnaud de Borchgrave

Spike band, a bracelet or necklace

Spike (Rugrats), a character from Rugrats and All Grown Up!

Spike (company), a video game company

The Spike, a 1997 novel by Damien Broderick

Spike (Buffyverse), a character from the cult television series Buffy the Vampire Slayer and Angel

The Spike, the name of one of the Titans in the game Crash of the Titans that's a cross between a porcupine and a crab.

Spike (monster truck) a monster truck, which is a team truck to Avenger, Brutus, and Wrecking Crew.

An adolescent male deer or elk