Edmund Spenser (c. 1552 - 13 January 1599), an English poet, author of The Faerie Queene, and a contemporary of William Shakespeare

Spencer Reid, on the series Criminal Minds

Marks & Spencer, a large retailer in the United Kingdom and other countries

Spencer Tracy, an American film actor

Frank Spencer, the leading character in the British sitcom Some Mothers Do 'Ave 'Em

Spencer W. Kimball, 12th President of The Church of Jesus Christ of Latter-day Saints

Spencer Carlin, a character on the teen drama series South of Nowhere on The N

Spencer County, Kentucky

Spencer, in the children's TV program Hallo Spencer, the mayor of the village, and presenter of the show

Spencer Tunick, American photographer

Spencer, Massachusetts

Spencer County, Indiana

Spencer, Oklahoma

Ozwell E. Spencer, a character in the Resident Evil video game series

Spencer Township, Minnesota

Spencer, Wisconsin

Spencer repeating rifle, a U.S. Army weapon popular from the American Civil War through the Plains Indian Wars

Spencer Chamberlain, American singer for Underoath

Spencer Krug, a singer, songwriter and keyboardist

Spencer (town), New York

Spencer (village), New York

Spencer, Iowa

Spencer, Indiana

Spencer, North Carolina

Spencer, South Dakota

Spencer Township, Michigan

Spencer (town), Wisconsin

Spencer, Idaho

Spencer Wells, American geneticist and anthropologist

Spencer, New South Wales, on the Central Coast

Spencer, Ohio

Spencer, West Virginia

A thin woolen vest, worn by women for extra warmth in winter

Spencer, Tennessee

Spencer (CDP), Massachusetts

Spencer, Nebraska

Spencer (GH), the Spencer family on General Hospital

Spencer's, a department store chain in British Columbia, Canada (1873 to 1948)

A short, close-fitting jacket, worn by women and children in the early 19th century

Spencer Locke, American actress

Spencer Gifts, a retail chain in the United States and Canada