Speech communication

Speak (film), the film based on Anderson's book

SPEAK (animal rights campaign)

SPEAK network (a Christian student campaigning network)

Speak, the pet of comic superhero The Tick.

SPEAK (Suicide Prevention Education Awareness for Kids), a Maryland-based organization for suicide prevention

SPEAK!!!, the 3rd album from The Mad Capsule Markets

Speak (artist), the Hungarian rap artist and internet pheonomenon famous for his anti-war video

Speak (album), the first album by the actress Lindsay Lohan

Speak (song), a song by the band Godsmack

Speak (Nickel Creek song), a single by progressive bluegrass band Nickel Creek.

Speak (novel), a novel by Laurie Halse Anderson

SPEAK (test), the Speaking Proficiency English Assessment Kit from the Educational Testing Service

Speak, young adult division of the publishing company The Penguin Group

S.P.E.A.K. Project-(Safe Practices Elevating Awareness and Knowledge)Fort Worth, Texas. Founded in 2007 by Kevin Ryan. A coalition of different agencies raising awareness on topics ranging from substance abuse to STD's/HIV