Skunk, an animal

Skunk works is a term used in engineering and technical applications for secret (black) projects

Jeff "Skunk" Baxter, American musician and defense consultant

Skunk Anansie, a British rock band

"Skunks," a song by Manitoba from their 2003 album Up in Flames

Skunk River, a tributary of the Mississippi

Double skunk, a term used to describe domination in sport after the game has been completed

Skunk cannabis, a potent strain of Cannabis grown through selective breeding and (often) hydroponics

Skunkweed, a name for Polemonium viscosum, a flowering plant in the genus Polemonium

Eastern Skunk Cabbage (Symplocarpus foetidus), a low growing, foul smelling plant in the genus Araceae

Skunked beer, beer that has been exposed to ultraviolet light, like sunlight too long.

Skunk Kusai, a villain from Osamu Tezuka's various works, most notably Astro Boy.

Skunk Rock, a genre of music combining skiffle and punk.