Six Degrees of Separation (film), a 1993 motion picture starring Will Smith based upon a play by John Guare with its basis in the theory of the same name

Six degrees of separation, the theory that anyone on earth can be connected to any other person on the planet through a chain of acquaintances that has no more than five intermediaries

Six Degrees of Inner Turbulence (song), the title track of the aforementioned album

Six Degrees of Kevin Bacon, a trivia game that requires a group of players to connect any film actor to Kevin Bacon in as few links as possible

Six Degrees of Inner Turbulence, a full-length studio album by progressive metal band Dream Theater

Six Degrees or 6˚, an American television series that began in the fall of 2006 on ABC

Six Degrees of Separation (Battlestar Galactica), an episode of the reimagined Battlestar Galactica television series

Six degrees of freedom, motion in three dimensional space, with three translation motions (up/down, left/right, forward/back) and three rotation motions (yaw, pitch, roll)

SixDegrees.com, a social network service website from 1997 to 2001

Six Degrees: The Science of a Connected Age, a science book by Duncan J. Watts, covering the application of network theory to sociology

Lonely Planet Six Degrees, Lonely Planet's flagship travel show

Six Degrees Records, a recording company noted for its catalog of recordings from international musicians and vocalists

SixDegrees.org, a social networking service intended to link people to charities, started by American actor Kevin Bacon