Sappho was an Ancient Greek poet. Sappho can also refer to:

Sappho (opera), an early opera by the French composer Charles Gounod

HMS Sappho (1837), a British warship

Sappho, Washington, an unincorporated community in the U.S. state of Washington

80 Sappho, an asteroid named after the poet

Sappho, the genus of the Red-tailed Comet hummingbird

Sappho Point, South Georgia