Saving Private Ryan, a 1998 film

Subtree pruning and regrafting, a method in computational phylogenetics

Southern Pacific Railroad

Strategic Petroleum Reserve

Society for Psychical Research

South Park Republican

Stop Prisoner Rape, Inc

Special Police Rifle, made by FN-Herstal

Sociopolitical Ramifications MUCK

Sive, Paget & Riesel, New York City environmental law firm

Mk 12 Special Purpose Rifle (aka Special Purpose Receiver), a modern rifle used by U.S. Special Forces

San Pedro Airport (IATA Code: SPR) in San Pedro Town, Belize

Shibuya Psychic Research, the business at the centre of Fuyumi Ono's Ghost Hunt.

Software Productivity Research, software benchmarking company led by Capers Jones

Special Purpose Register, a type of processor register in a microprocessor

Specialist registrar, a training grade for doctors in the United Kingdom's National Health Service.

Surface plasmon resonance, a physical phenomenon and a biochemical experimental technique