SMC Engineering, private Estonian mechanical engineering company SMC.

Saint Mary's College of California

San Miguel Corporation, a Philippine conglomerate

San Mateo County

Super Milk Chan Show, a comedy anime show made in Japan by Studio Pierrot.

Smooth Muscle Cells

Surface Mounted Components, the kind of electronic components used in Surface Mounted Technology

Stewart's Melville College, a boys' private school in Edinburgh, Scotland

Saint Michael's College, in Colchester, Vermont, USA

Self-modifying code

Sequential Monte Carlo method, a problem resolving method in Mathematics

St. Mary's College of Maryland

Senior Mathematical Challenge, a Mathematics Challenge for students aged between 13-18, organised by the United Kingdom Mathematics Trust

Sonic Mega Collection

SmartMedia Card

Singapore's Speak Mandarin Campaign

Sufi Muslim Council (SMC), a major British organization that represent a small number of UK Muslims.

Santa Monica College

Speed Modelling Contest, also Challenge or Competition (A contest between 3d artists).

Secure multiparty computation, a cryptography problem

SMC connector, used in radio-frequency circuits

Single Member Constituency, a constituency in the political system of Singapore

Sindh Medical College, a well known medical school in Karachi, Pakistan

Spartanburg Methodist College, an institute of higher learning in Spartanburg, SC.

Small Magellanic Cloud

Scottish Mountaineering Club

Structural Maintenance of Chromosomes

Supreme Military Council, Ghana, the ruling military council in Ghana from 1975 to June 4 1979

Science Media Centre (UK press office improving the representation of science in the news)

St. Mary's College, an all-boys college in Mauritius

SMC Marine Services (ocean going bulk cargo shipping)

System Management Controller, a chip that controls power functions on Apple computers

Space and Missile Systems Center, AFSPC, United States Air Force

SMC Networks, computer network company

St. Mary's Convent Inter College, Allahabad

Samsung Medical Center, one of the biggest hospital in South Korea.

The Spin Muon Collaboration, the successor to the European Muon Collaboration

Storch Music Company (SMC), Record label owned by Scott Storch

SMC Corporation of America, pneumatic automation products

Sun Metals Corporation, an Australian Zinc refinery

SMC Corporation of America, a company producing pneumatic automation products

Sheet Moulding Composite or Sheet Moulding Compound