George Robert Sims, British journalist and author

The Sims 2, the second game in The Sims series

The Sims, the first game in The Sims series

Secondary ion mass spectrometry, a type of spectrometry

Sim (Maxis Sim games), the name of the humanoid characters that populate Maxis Sim games

J. Marion Sims, American gynaecological surgeon

Subscriber Identity Module, removable smart card ICC

The Sims, a life simulation computer and video game series by designer Will Wright (see List of The Sims games)

Charles Sims (painter), British painter

Sims, a rapper with the Doomtree label

Michael Sims, an American non-fiction writer

Sims, Illinois, a village in the United States

Student information system, computer software for managing student records

Thomas Sims, subject of a notorious American fugitive slave case

Sims (novel), a book by F. Paul Wilson about genetically enhanced chimpanzees used as a labor force

SIMS.net, a School Information Management System developed by Capita

Howard Sims ("Sandman" Sims), American vaudeville dancer

Christopher A. Sims, American economist

SIMS (video game company), a Japanese video game publisher and developer

John Sims, botanist

Services Institute of Medical Sciences, a medical school attached to Services Hospital in Lahore