Securities and Exchange Commission (SEC), United States.

single error correction (see error correcting code).

Simple Electronic Computer, a computer from about 1950.

In biology, the Sec pathway is a major route of protein translocation across various cell membranes

Social Evolutionary Computation.

In general context, an abbreviation for second.

Samsung Electronics Corporation

Size Exclusion Chromatography.

State Electricity Commission of Victoria.

Securities and Exchange Commission (SEC), Philippines.

Space Environment Center.

State Energy Commission of Western Australia.

In mathematics and geometry, an abbreviation for secant.

State Examinations Commission, Ireland.

Southeastern Conference (SEC), a major NCAA conference.

"Dalek Sec", a member of the fictional Cult of Skaro from the television series Doctor Who.