Route 66 (film) - A movie to be released by Dreamworks in 2010.

Route 66 Rendezvous - an annual car show and street fair held in San Bernardino, California

Route 66 (TV series) - a 1960s television program

U.S. Route 66

Route 66 Clothing Co. - a K-mart clothing line named after the route.

Route 66 (Cheetah Girls) - the Cheetah Girls single

Route 66 (song) - a popular song

Various other highways (see List of highways numbered 66)

Route 66 Records, a record label

ROUTE 66 (Company) - a company named after the route

The 2001 working title of the Pixar movie Cars. Renamed in favor of avoiding reference to the aforementioned TV series, and also features a cover version of the aforementioned song.

Route 66 Raceway - A drag racing strip in the Chicago-suburb of Joliet

Root 66 - A brand of root beer test marketed by Anheuser-Busch from 1979-1981

Route 66 Gold Coast Gold Coast, Queensland, Australia