Roe v. Wade, the court case that legalized abortion in the United States

Marie Roe, married name of Marie Stopes

Rubies of Eventide (RoE), a medieval fantasy massively multiplayer online role-playing game.

Jane Roe and Richard Roe, pseudonyms for anonymous litigants in the United States legal system

Mallee (biogeographic region), formerly known as Roe Botanical District

Doom 3: Resurrection of Evil, an expansion pack for the video game Doom 3.

The Roe deer, the deer of Britain and Europe

Roe (egg), the fully ripe egg masses of fish and certain marine invertebrates

Charles Roe (1715–1781), English industialist

Sir Thomas Roe (or Row), English diplomat of the Elizabethan and Jacobean periods

Norma McCorvey, known as "Jane Roe" in Roe v. Wade

Kris Roe, member of The Ataris

Michael Roe, American record producer

Electoral district of Roe

Francis Asbury Roe, United States Navy admiral

Alliott Verdon Roe, British aircraft manufacturer

Tommy Roe, American pop music singer and songwriter

Roe, Arkansas, a town located in Monroe County, Arkansas

Edward Payson Roe, American novelist

The River Roe in Co Londonderry, Northern Ireland

Eugene Roe, medic of the 506th Parachute Infantry Regiment

David Roe, English professional snooker player

USS Roe, the name of two ships in the United States Navy

Raigh Roe, former Australian of the Year

Charles H. Roe the UK coachbuilding company

James M. Roe, American astronomer

Dame Marion Roe, United Kingdom politician

The Roe River, Montana, the shortest river in the world

John Septimus Roe, first Surveyor-General of Western Australia. Roe Highway was named for him upon its construction.

Reginald Heber Roe, 2nd Headmaster of Brisbane Grammar School, 1st Vice Chancellor of University of Queensland