The silent film, The Road to Ruin (film).

A weekly internet video show created by the Canadian band Sum 41.

The Road to Ruin (novel), a John Dortmunder novel by Donald E. Westlake.

The Road to Ruin (play), a ninteenth-century theatrical production.

Road to Ruin, the 1978 album by The Ramones.

The Road to Ruin (album), a 1970 folk album by John and Beverley Martyn.

The exploitation film directed by Dorothy Davenport and Melville Shyer, Road to Ruin (1934 film).

The mainstream film starring Peter Weller, Road to Ruin (1991 film).

The song by hard rock band Mr. Big, on their 1991 album Lean Into It.

The song by British rock band The Libertines, on their 2004 album The Libertines.

The song by Canadian heavy metal band Annihilator, on their 1990 album Never, Neverland.