Monty Python, a British comedy troupe

Python (programming language), a computer programming language

Python (film), a 2000 horror film by Richard Clabaugh

Python missile, a series of Israeli air-to-air missiles

Colt Python, a firearm

Python (mythology), the oracular serpent of Delphi

Python, a South Devon Railway Buffalo class steam locomotive

Python (genus), a group of snakes

Python (roller coaster), a defunct roller coaster (Busch Gardens Africa)

Pythonidae, a family of snakes

Armstrong Siddeley Python, an early turboprop engine

Python II, the 2002 sequel to the above film

Python Automobile, a sports car

Python, the compiler part of CMU Common Lisp implementation