Prime number, a natural number which is only divisible by 1 and itself

Prime (novel), a novel by Poppy Z. Brite

Metroid Prime, a series of games in the popular franchise Metroid

Prime (lending market sector), within which lending product providors are focused on selling products (mortgage, loan or credit card) to the individual who is high-value and/or has a good credit history - as opposed to the subprime market sector.

Prime Television, a television network in Australia

Uru: Ages Beyond Myst, an adventure game for the PC developed by Cyan Worlds

Prime (liturgy), a liturgical office (service or ceremony)

Prime Computer, a producer of minicomputers from 1972 until 1992

Prime (comics), a comics character

Prime Television New Zealand

Prime time

Prime (symbol), the ′ mark

TVtropolis, a CanWest-owned Canadian television channel previously known as Prime

Prime ideal, subset of a ring in mathematics

3′ end and 5′ end ("three prime end", "five prime end") in biochemistry

Prime lens, having a fixed focal length

Prime (film), a romantic comedy

Prime Network, a defunct cable sports network in the United States

Prime rate

Prime model, a model as simple as possible in mathematical model theory

Prime knot, a knot that cannot be written as the knot sum of two nontrivial knots

Prime 3-manifold, a 3-manifold that cannot be written as the connect sum of two nontrivial 3-manifolds.

Prime form in music

Prime (planet), a designation of a planet relative to its system in Science Fiction.

Prime Minister, the highest Executive Office with real powers in certain governments.

Prime, a title used by Autobot leaders in Transformers, most notably Optimus Prime and Rodimus Prime

The Primes is another name for the Dyson Aliens in Peter Hamilton's Commonwealth Saga.

Programme for Rebuilding and IMproving Existing schools - a programme of the Singapore Ministry of Education.