Alexander Portnoy, the protagonist of Philip Roth's 1969 novel Portnoy's Complaint

Michael Portnoy, U.S. performance artist

Edan Portnoy, U.S. rapper, DJ, and producer

Gary Portnoy (born 1956), U.S. singer/songwriter

Jerry Portnoy (born 1943), U.S. harmonica musician

Mike Portnoy (born 1967), U.S. drummer and band leader (Dream Theater)

Portnoy, a comic strip character from Bloom County.