Harry Potter and the Philosopher's Stone, a fiction novel

Harry Potter and the Philosopher's Stone (film), the film based on the novel

Harry Potter and the Philosopher's Stone (video game), the game based on the novel

Philosopher's Stone (Fullmetal Alchemist), a central plot element in a Japanese television series

Philosopher's stone, the medieval term for the alchemical secret of converting lead into gold

The Philosopher's Stone (album), a 1998 Van Morrison music record of outtakes from throughout his career.

The Philosopher's Stone, a quest for the secrets of alchemy, a book by Peter Marshall.

Indiana Jones and the Philosopher's Stone, a 1995 novel by Max McCoy

The Fabulous Philosopher's Stone (Disney comics), a 1945 Donald Duck story

Philosopher's Stone is also a popular name for both Psilocybe tampanensis and Psilocybe mexicana, psychedelic mushrooms.