Persistent organic pollutant, an organic compound that is resistant to degradation and persists in the environment

Persistent Uniform Resource Locator, a Uniform Resource Locator (URL) that persists over time

Persistent Systems, a software company based in Pune, India

Persistent world, a type of virtual world

Persistent data structure, a data structure in computing which preserves the previous version of itself when it is modified

Persistent Trillium, a flowering plant