William Penn, Jr., son of William Penn

Sean Penn, American actor

John Penn (engineer) (1805–1875), British marine engine engineer, invented lignum vitae bearing for propellor shafts, twice president of the Institution of Mechanical Engineers.

BJ Penn, a mixed martial arts fighter

Arthur Penn, American film director and producer

Kal Penn, American actor

Chris Penn, American actor (brother of Sean Penn)

Michael Penn, American singer and songwriter

Irving Penn, an American photographer

Penn Lake Park, Pennsylvania, United States

Robin Wright Penn, American actress

Penn, Pennsylvania, United States

Penn, Buckinghamshire, United Kingdom

Penn, West Midlands, United Kingdom

Hannah Callowhill Penn, wife of the William Penn

Leo Penn, American actor

Alexander Penn Israeli poet

Alexander Penn Wooldridge, American mayor of Austin, Texas from 1909 to 1919

Penn Township, several municipalities in the United States

John Penn (architect) (1921–2007), a British architect

Michael Penn (baseball), pitcher, Kansas City Royals

University of Pennsylvania, "Penn", a private research university in Philadelphia, Pennsylvania, USA

Pennsylvania State University, "Penn State", state-related university in State College, Pennsylvania, USA

John Penn (delegate) (1741–1788), Continental Congressman from North Carolina and signer of the United States Declaration of Independence

John Penn (governor) (1729–1795), a lieutenant governor and later proprietor of colonial Pennsylvania

John Penn (writer) (1760–1834), son of Thomas Penn

Robert Penn, African-American sailor, recipent of the Medal of Honor during the Spanish-American War

William Penn (admiral), English admiral

Penn Jillette, a member of the comedy and magic duo Penn & Teller.

Penn Club of New York City, located in New York City

Penn (automobile), manufactured in Pittsburgh from 1910 until 1913

Penn (Buffyverse), a one-time vampire villain featured in the Angel episode Somnambulist