pUC, (short for "produced at the University of California"), a bacterial plasmid used in molecular cloning and other molecular biology applications

Pacific Union College, a liberal arts college located in the Napa Valley, owned and operated by the Seventh-day Adventist Church

Pontificia Universidad Católica de Chile, a prestigious Chilean university

Pathé Unlimited Card, a pass for unlimited entrance at 12 movie theaters in the Netherlands

Personal Unblocking Code, a GSM mobile phone feature

Pre University Course, an intermediate course required for admission to Indian universities

Public Utilities Commission, a United States government agency

Presidential Unit Citation, a military award that is the senior unit award presented by many nations

Pontifícia Universidade Católica, a wide group of Brazilian universities

Carbon County Airport in Price, Utah has an IATA airport code of PUC.