Otis, the chameleon creature, a minor character from the television cartoon Hercules

James Otis, a lawyer in colonial Massachusetts who was an early advocate of the political views that led to the American Revolution

Elisha Otis, inventor of a safety device for hoisting machinery, who went on to invent the first passenger elevator

Otis Redding, the musician

Otis, the main character in the 2006 movie Barnyard (film)

Harrison Gray Otis (lawyer) (1765-1848), Representative and a Senator from Massachusetts

Otis (Prison Break episode)

Otis R. Bowen, the former governor of Indiana and former United States Secretary of Health and Human Services

Otis, Colorado

Otis tarda genus, the Great Bustard

Otis, Massachusetts

The Otis Elevator Company, a subsidiary of United Technologies Corporation, and the world's largest manufacturer of vertical transportation systems, principally elevators and escalators

Otis, a puppy in The Adventures of Milo and Otis

Otis B. Driftwood, a fictional character that has appeared in the Rob Zombie horror films House of 1000 Corpses and The Devil's Rejects taken from the character of the same name popularized by Groucho Marx

Elwell Otis, an American general who served in the Philippines during the Spanish-American and Philippine-American wars

Amos Otis, a professional baseball player

Otis township, Saguenay-Lac-Saint-Jean, Quebec

Otis Orchards-East Farms, Washington

Otis Campbell, the town drunk on the Andy Griffith Show

Otis, Kansas

Otis, Maine

Otis (Superman), an associate of Lex Luthor, in the films Superman and Superman II

Harrison Gray Otis (1837-1917), a publisher of the Los Angeles Times

Otis, Oregon

Otis (album)

Otis the Aardvark, a BBC puppet character

Otis King, inventor

Otis Grant, a professional boxer

Otisstraße, a street and underground metro station in Berlin on the U6 line

William Otis, inventor of the steam shovel

Otis Nixon, former MLB player

Otis College of Art and Design, a private four-year art college located in Los Angeles, California formerly known as Otis Art Institute and Otis/Parsons