Orsino is a novel by Romain Rolland.

Orsino's Songs is an album by Clare Teal.

John Orsino (born 1938), Major League Baseball catcher

Duke Orsino is a character in Shakespeare's Twelfth Night.

Orsino was a small town on Merritt Island in Brevard County, Florida, which was one of several subsumed into the John F. Kennedy Space Center.