"Once in a Lifetime" (Talking Heads song), a song from Remain in Light

Once in a Lifetime (box set), a box set by Talking Heads

Once in a Lifetime (documentary), a 2006 documentary about the New York Cosmos soccer team

"Once in a Lifetime" (Keith Urban song), a song from Love, Pain & the whole crazy thing

"Once in a Lifetime" (Eurovision song), a song that represented Estonia in Eurovision 2000