Edna O'Brien, novelist, member of Aosdána

Tim O'Brien (author), (born 1946), American author

Keiko O'Brien, fictional character, wife of Miles O'Brien in Star Trek: The Next Generation and Deep Space Nine

Mark O'Brien (Ontario politician), Green Party candidate in the 2004 Canadian federal election

O'Brien is a common surname of Irish origin. The name is Gaelic, and its original language version is Ua Briain or Ó Briain (pronounced: Ew-Breen/Oh-Breen), meaning 'descendant of Brian'. It carries the sense ‘eminence’, i.e. ‘exalted one’. The Brian referred to is in most cases the ancient Irish king Brian Boru, or in Gaeilge - Brian Bórumha mac Cennétig. This O'Brien family ruled over Munster after Brian Boru's death, and later supplied the rulers of Thomond until the area became incorporated into the English holdings in Ireland in the Tudor period (but see the de Clare family). The O'Brien rulers were then given the titles of Earl of Thomond and Baron Inchiquin, the latter of which survives today and is held by the descendants of the ancient rulers. Two mottoes have been associated with the O'Brien clan: firstly, Vigueur de dessus: 'Strength from above' and secondly, 'Lamh laidir an uachtar' 'The strongest arm uppermost' [1]. Other variants of this surname are O'Bryan, O'Brian, O'Breen', Breen, Bryant ("T" for Thomond) and many more.

Kate O'Brien, British fashion & television make-up artist

Terry O'Brien squadron leader with Orde Wingate's Chindits who flew deep behind Japanese lines and later wrote a trilogy of war's flying: Out of the Blue (1984), The Moonlight War (1987), and Chasing After Danger (1992).

Richard O'Brien, (born 1942), Rocky Horror Show and Rocky Horror Picture Show writer and actor

Conan O'Brien, (born 1963), US comedian and talk show host

Robert C. O'Brien, author of Mrs. Frisby and the Rats of NIMH

Larry O'Brien (Canadian politician), Canadian entrepreneur and politician; Mayor of Ottawa, late 2006 to present

Aidan O'Brien, Irish race horse trainer

Larry O'Brien, political and basketball figure

Flann O'Brien, At Swim-Two-Birds

Soledad O'Brien American Television journalist, currently host of CNN's American Morning

Edwin Frederick O'Brien, Archbishop of Baltimore

Miles O'Brien (Star Trek), fictional character in Star Trek: The Next Generation and Deep Space Nine

Ed O'Brien, (born 1968), English musician, guitarist for Radiohead

Keith Michael Patrick O'Brien, current Roman Catholic Cardinal Archbishop of Saint Andrews and Edinburgh

Cathy O'Brien, purported American child-slave/sex-abuse victim

George H. O'Brien, Jr (1926-2005) Korean War Congressional Medal of Honor Recipient.

Andrew O'Brien, an Irish association football player

O'Brien County, Iowa, United States

Pat O'Brien (actor), American movie actor

Alex O'Brien, a professional American tennis player

George O'Brien (painter) (1821-1888), the New Zealand painter

Shauna O'Brien American erotic film star.

Bronterre O'Brien, (1805-1864), British Chartist

Jim O'Brien, professional basketball coach

Vincent O'Brien, Irish race horse trainer

George O'Brien (Actor) (1899-1985) the American silent movie actor.

O'Brien (1984), a character in Nineteen Eighty-Four

John P. O'Brien, Mayor of New York City

Dave O'Brien, television announcer of the Boston Red Sox

Kerry O'Brien (politician), Australian Senator

Tim O'Brien (musician), (born 1954) American musician

Kerry O'Brien, Australian ABC Television Current Affairs Presenter

Stephen O'Brien UK conservative politician for Eddisbury

Marty O'Brien, American guitarist in 3-Faced

Fergal O'Brien, Irish professional snooker player

Miles O'Brien (journalist), journalist and CNN anchor

Eugene O'Brien, actor of the silent film era (born Louis O'Brien)

Billy O'Brien (1860-1911), American baseball player

Erin Joanne O'Brien, American actress born in 1935

George Miller O'Brien (1917-1986) Member, U.S. House of Representatives (from Illinois), 1973-1986.

George O'Brien (cricketer) (born 1984) the Bermudian cricketer

Mick O'Brien (musician), Traditional Irish Musician

Terence Albert O'Brien (1600-1651), beatified Irish bishop

Michael O'Brien (swimmer) (born 1965), American freestyle swimmer

Dermod O'Brien (1865-1906), Irish painter

Kerry O'Brien, Australian middle-distance runner

Erin O'Brien (writer), American writer

USS O'Brien

Robert O'Brien, American racing driver

James O'Brien, see separate disambiguation page

Richard Baptist O’Brien, (1809-1885), Irish priest, author and nationalist

O'Brien, Oregon, United States

Patrick O'Brien, musician-lutenist

George Thomas Michael O'Brien former governor of Fiji

George O'Brien (footballer) the former Southampton F.C. footballer

John O'Brien (soccer), American soccer player