The Moonstone, a novel by Wilkie Collins

Moonstone, Ontario, a small hamlet near Coldwater, north of Barrie, in Ontario, Canada

Moonstone, one of the three keys to Atlantis in the computer game Indiana Jones and the Fate of Atlantis

Moonstone, the name of the machine used to select numbers in the Lotto draw in the UK's National Lottery.

Moonstone (comics), a Marvel Comics supervillainess, also known as Meteorite

Moonstone, a weapon used by one of the main characters in Princess Gwenevere and the Jewel Riders

The Moonstone, from Erin Hunter's Warriors novel series

Moonstone Books, a publisher of graphic novels and comic books.

Moonstone: A Hard Day's Knight, a 1992 computer game

Moonstone, a song by Cat Stevens released in his 1967 album New Masters.

Moonstone, an episode in The Outer Limits

Moonstone (company), a Japanese visual novel studio

Moonstone a type of gemstone (see orthoclase)

Moonstones, a major plot element in Overwork Studios' Skies of Arcadia.

Moon Stone, an item in the Pokémon video games and anime which is used to trigger evolution in Pokémon such as Clefairy