The Mona Lisa is a world-famous painting by Leonardo da Vinci. Mona Lisa may also refer to:

Mona Lisa Smile, a 2003 film.

"Mona Lisa", a song by Slick Rick on his 1988 debut album, The Great Adventures of Slick Rick

"Mona Lisa", a song by Wycelf Jean, featuring The Neville Brothers on backing vocals, on Jean's 1997 solo debut album, The Carnival

Mona Lisa (singer), an R&B singer

"Mona Lisa" (Britney Spears song), a song by Britney Spears on her 2005 EP, Someday (I Will Understand)

Mona Lisa (film), a 1986 British film

"Mona Lisa" (Nat King Cole song), a song by Nat King Cole on the soundtrack of the 1950 film Captain Carey, U.S.A.

Monalisa (actress), an Indian actress

Mona Lisa (opera), an opera by Max von Schillings

"Mona Lisa" (Guster song), a song by Guster on their 1995 debut album, Parachute

Mona Lisa (crater), a crater on Venus

Mona Lisa (TMNT), an obscure Ninja Turtles character.